Final Analysis Of Landmark Ipass Study Confirms That Iressa (gefitinib) Is A Valuable Option For The

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MEDIA RELEASE PR41659


Final Analysis of Landmark IPASS Study Confirms That IRESSA (Gefitinib) is a Valuable

Option for the First-Line Treatment of Patients With Advanced NSCLC with EGFR

Activating Mutations


MILAN, Oct. 12/ PRNewswire-AsiaNet/ --


    This press release has been made available on worldwide (excluding US)

press communication media for the benefit of correspondents writing for the

medical professional press. Differing national legislation, codes of

practice, medical practice etc mean that you should contact your local AZ

press office to obtain information designed for use in your country.

Not for US or Canadian journalists/publications.


    Mature data from the IPASS study, presented today at the 2010 ESMO

congress, showed that overall survival (OS) was similar, with no significant

difference, between IRESSA (an EGFR tyrosine kinase inhibitor (TKI)) and

carboplatin/paclitaxel (doublet chemotherapy) in the overall population

(HR=0.90, 95% CI 0.79-1.02, p=0.11, median OS 18.8 vs. 17.4 months). Neither

was there a significant difference between treatment arms for OS in the

subgroups defined by EGFR mutation status: EGFR mutation-positive patients

(HR=1.00, 95% CI 0.76-1.33, median OS 21.6 vs. 21.9 months); EGFR

mutation-negative patients (HR=1.18, 95% CI 0.86-1.63, median OS 11.2 vs.

12.7 months); and patients whose EGFR mutation status was unknown (HR=0.82,

95% CI 0.70-0.96, median OS 18.9 vs. 17.2 months).[1]






    The mature IPASS OS data confirm that patients with EGFR

mutation-positive advanced non-small cell lung cancer (NSCLC) had better

outcomes, regardless of which treatment arm they were in, compared to

patients with EGFR mutation-negative disease. Median survival times were

around 22 months for EGFR mutation-positive patients, but only 11-12 months

for EGFR mutation-negative patients.[1] The majority of EGFR 

mutation-positive patients in IPASS received an EGFR-TKI at some point as 64% 

of those randomised to carboplatin/paclitaxel later received an EGFR-TKI as 

subsequent therapy.


    "I believe that progression-free survival is a better endpoint than

overall survival for evaluation of treatment effect in the first-line

setting," said IPASS investigator, Professor James Yang from National Taiwan

University Hospital. "However, the IPASS data show that EGFR

mutation-positive patients have better survival outcomes than EGFR

mutation-negative patients, regardless of whether they were randomised to

IRESSA or chemotherapy. Lung cancer patients should be tested to determine

their EGFR mutation status, as EGFR mutation-positive patients benefit from

treatment with IRESSA through longer progression-free survival, improved

control of their symptoms and better quality of life, compared with doublet

chemotherapy. It's important to consider very carefully when choosing a

first-line treatment for advanced NSCLC, as many patients in clinical

practice will not receive further active treatment."


    Analysis of the primary endpoint of IPASS in 2008 demonstrated that

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IRESSA was superior to carboplatin/paclitaxel in terms of progression-free

survival (PFS) in the overall population (HR 0.74, 95% CI 0.65-0.85,

p<0.001).[2] Further analysis of the data demonstrated that IRESSA's PFS

superiority in the overall population was driven by the effect of IRESSA vs.

carboplatin/paclitaxel in the subgroup of EGFR mutation-positive patients.[2]

In these patients, compared with carboplatin/paclitaxel, IRESSA reduced the

risk of progression by 52% (HR=0.48, 95% CI 0.36-0.64, p<0.001) and median

progression-free survival was increased from 6.3 to 9.5 months. In addition,

IRESSA provided significant benefits in objective response rate, quality of

life and symptom improvement compared with carboplatin/paclitaxel in EGFR

mutation-positive patients.[2,3]


    "IPASS is a landmark study, which changed the way the oncology community

viewed lung cancer," said Alison Armour, Medical Science Director for

AstraZeneca. "It was anticipated that the significant IRESSA progression-free

survival benefit may not translate into an overall survival benefit, due to

the large amounts of subsequent treatment that patients could have received

following disease progression on their randomised first-line treatment. IPASS

data reinforce that there should be a move towards recognising that lung

cancer is a complex disease with distinct subtypes requiring targeted

medicines."


    The IPASS data from 2008[2] formed part of the data package leading to the

current indication for IRESSA in Europe.[4] The ESMO Clinical Practice

Guidelines[5] for metastatic NSCLC state that first-line treatment with a TKI

is an option in patients with tumours harbouring an activating EGFR mutation.

IRESSA is currently indicated in Europe for the treatment of patients with

EGFR mutation-positive advanced NSCLC.[4] Outside of Europe, IRESSA is licensed

in a further 44 countries, labelled indications vary from country to country.


    Editors Notes


    About IPASS[2]


    IRESSA Pan-ASia Study (IPASS) was a Phase III open label, randomised,

parallel-group study that assessed the efficacy, safety and tolerability of

IRESSA versus standard doublet chemotherapy (carboplatin/paclitaxel) as

first-line treatment in a clinically selected population of 1,217 patients

from Asia. The patients had advanced NSCLC and had not received prior

chemotherapy for advanced disease. Their tumours were of adenocarcinoma

histology. They had either never smoked, or were former light smokers (ceased

smoking at least 15 years ago and <= 10 pack-years exposure).


    The primary endpoint was progression-free survival (PFS: length of time a

patient lives without their cancer growing or spreading).


    The secondary endpoints included overall survival, objective response

rate, quality of life and safety.


    IPASS was published in The New England Journal of Medicine and marked the

first time a targeted monotherapy has demonstrated significantly longer PFS

than doublet chemotherapy in the first-line treatment of EGFR

mutation-positive advanced NSCLC.


    About IRESSA (gefitinib)


    Mode of Action: gefitinib is an EGFR-TKI (epidermal growth factor

receptor tyrosine kinase inhibitor), which targets and blocks the activity of

the EGFR-TK, an enzyme that regulates intracellular signalling pathways

implicated in cancer cell proliferation and survival. Growth factor

signalling has been identified as a key driver of tumour growth and spread in

a wide range of cancers.


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    IRESSA (250 mg) is a once-daily oral therapy.


    IRESSA is approved in the EU for the treatment of patients with locally

advanced or metastatic NSCLC with activating mutation of EGFR-TK. Outside of

Europe, IRESSA is licensed in a further 44 countries - labelled indications

vary from country to country.


    IRESSA has a well-established, generally well-tolerated side effect

profile and is not typically associated with the cytotoxic side-effects

commonly seen with chemotherapy. The most commonly seen side-effects of

IRESSA are mild-to-moderate rash and diarrhoea.


    To view an IRESSA MOA video, please click here:



    To date, the number of patients who have taken IRESSA is over 300,000 and

the maximum time a patient has remained on gefitinib therapy is in excess of

eight years.[6]


    About EGFR mutation testing


    Epidermal growth factor receptor (EGFR) is a protein found on the surface

of cells to which proteins or ligands such as epidermal growth factor (EGF)

bind. When EGF attaches to EGFR, it activates the tyrosine kinase enzyme,

triggering reactions that cause the cells to grow and multiply.


    The EGFR gene can have mutations that cause the EGFR to be permanently

activated, which in turn activates the tyrosine kinase enzyme, triggering

reactions that cause the cells to grow and multiply. Those patients who have

these mutations have EGFR mutation-positive disease.


    NSCLC is the more common of the two forms of lung cancer. The other is

small-cell lung cancer (SCLC), which accounts for 15% of cases, whereas NSCLC

accounts for approximately 85%.[7]


    Approximately 10-15% of NSCLC patients in Europe[4,8,9] and 30-35% of

NSCLC patients in Asia will have EGFR mutation-positive NSCLC. [10,11]


    EGFR mutation-positive NSCLC can be identified through biopsy testing at

the point of diagnosis. This is an additional test that the oncologist

requests along with other standard diagnostic tests (histology testing) to

identify what kind of lung cancer a patient has. If done at the same time,

this can avoid any delay in the start of treatment.


    A number of different laboratory tests are currently available for this

purpose, including DNA sequencing, Clamp (especially in Japan) and Melt

analysis. In addition, there is a mutation detection technique called the

TheraScreen EGFR29(R) (DxS).


    For more information on EGFR mutation testing, please visit:



    About AstraZeneca


    AstraZeneca is a global, innovation-driven biopharmaceutical business

with a primary focus on the discovery, development and commercialisation of

prescription medicines. As a leader in gastrointestinal, cardiovascular,

neuroscience, respiratory and inflammation, oncology and infectious disease

medicines, AstraZeneca generated global revenues of US $32.8 billion in 2009.

For more information please visit: http://www.astrazeneca.com


    REFERENCES:


To view this and other AsiaNet releases please visit http://www.asianetnews.net

    1. Yang C-H et al. Final overall survival (OS) results from a phase III:

randomised, open-label, first-line study of gefitinib (G) v

carboplatin/paclitaxel (C/P) in clinically selected patients with advanced

non-small cell lung cancer (NSCLC) in Asia (IPASS). Presented at the European

Society of Medical Oncology (ESMO) Congress, 2010.


    2. Mok T et al. Gefitinib or carboplatin-paclitaxel in pulmonary

adenocarcinoma. New England Journal Medication; 361: 947-957. 2009


    3. Thongprasert S et al. Quality of life in a randomised Phase III

first-line study of gefitinib vs. carboplatin/paclitaxel in clinically

selected Asian patients with advanced non small cell lung cancer (IPASS).

Presented at IASLC-ESMO meeting, April 2010.


    4. IRESSA summary of product characteristics (



    5. D'Addario G et al. Metastatic non-small-cell lung cancer: ESMO

Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals

of Oncology; 21 Suppl 5:v116-9. 2010.


    6. AstraZeneca data on file. 2010.


    7. Allen J et al. Journal of the National Comprehensive Cancer Network; 6

(3): 285-93. 2008.


    8. Cortes-Funes H et al. Epidermal growth factor receptor activating

mutations in Spanish gefitinib-treated non-small-cell lung cancer patients.

Annals of Oncology; 16(7);1081-1086. 2005.


    9. Rosell R et al. Screening for epidermal growth factor receptor

mutations in lung cancer. New England Journal of Medicine; 361:958-967. 2009.


    10. Tokumo M et al. The relationship between epidermal growth factor

receptor mutations and clinicopathologic features in non-small cell lung

cancers. Clinical Cancer Research; 11; 1167-1173. 2005.


    11. Yoshida K et al. Prospective validation for prediction of gefitinib

sensitivity by epidermal growth factor receptor gene mutation in patients

with nonsmall cell lung cancer. Journal of Thoracic Oncology; 2(1); 22-28.

2007.


   SOURCE: AstraZeneca






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